The PORTEC-3 trial showed that patients with stage III disease who received chemoradiation therapy followed by four cycles of carboplatin and paclitaxel chemotherapy had better overall and 5-year ...

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In PORTEC-3, all but one (95.8%) of the HER2-positive ECs were classified as p53abn. Given this strong association, we additionally performed DISH on all p53abn EC with absent or any faint membranous staining to ascertain the HER2 status assignment by IHC was correct. In correspondence to the IHC results, none of these p53abn EC showed …

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Methods: In this multimethod analysis, data from 1801 women participating in the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials were used for statistical analyses and causal inference. The cohort included 714 patients with intermediate-risk endometrial cancer, 427 patients with high-intermediate risk endometrial cancer, and …

FFPE tissue was collected from 423 consenting patients from 5 of the 6 clinical trial groups participating in the PORTEC-3 clinical trial. 7 The design and results of the PORTEC-3 trial have been reported previously 7 and are further described in the Data Supplement. Briefly, this international phase III trial enrolled patients with high-risk ...

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Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial. Lancet Oncol. 2018; 19 : 295-309

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The PORTEC-3 trial was initiated to investigate the benefit of adjuvant chemotherapy during and after radiotherapy (chemoradiotherapy) versus pelvic radiotherapy alone for women with high-risk endometrial cancer. Methods PORTEC-3 was an open-label, international, randomised, phase 3 trial involving 103 centres in six clinical

PORTEC-3 is registered with ISRCTN, number ISRCTN14387080, and ClinicalTrials.gov, number NCT00411138. Results: 686 women were enrolled between Nov 23, 2006, and Dec 20, 2013. 660 eligible patients were included in the final analysis, of whom 330 were assigned to chemoradiotherapy and 330 were assigned to radiotherapy. Median follow …

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3 1 Samples' DNA were sequenced using the AmpliSeq Cancer Hotspot Panel V.5, a panel consisting of 2 two primer pools designed to detect somatic cancer hotspot mutations covering 82 genes, including 3 the complete POLE exonuclease domain and TP53.Libraries were prepared using 42-84ng of DNA 4 and each sample labelled with a unique barcode …

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In March 2018, The Lancet Oncology published the initial results from the PORTEC-3 trial. 1 PORTEC-3 was an open-label, multicenter, phase III randomized trial that compared …

5502 Background: Women with high-risk endometrial cancer (HREC) are at increased risk of distant metastasis and endometrial cancer-related death. The randomized PORTEC-3 intergroup trial was initiated to investigate the benefit of adjuvant chemotherapy during and after radiotherapy (CTRT) versus pelvic radiotherapy (RT) alone for women with HREC. …

Purpose: The survival results of the PORTEC-3 trial showed a significant improvement in both overall and failure-free survival with chemoradiation therapy versus pelvic radiation therapy alone. The present analysis was performed to compare long-term adverse events (AE) and health-related quality of life (HRQOL). Methods and materials: In the study, …

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Aims: Quality assurance in radiotherapy (QART) is essential to ensure the scientific integrity of a clinical trial. This paper reports the findings of the retrospective QART assessment for all centres that participated in PORTEC-3; a randomised controlled trial that compared pelvic radiotherapy with concurrent chemoradiotherapy to the pelvis followed by …

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PORTEC-3 showed an improvement in "failure-free survival", which is the time from diagnosis to the cancer returning or death from the cancer. It is still an important result given that if the cancer returns it may not be possible to cure it.

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The PORTEC 3 study was supported in the UK by CRUK (C7925/A8659). Participation in the PORTEC-3 trial by ANZGOG and TROG were supported by the NHMRC Project Grant 570894 (2008) and by a Cancer Australia Grant (awarded through the 2011 round of the Priority-driven Collaborative Cancer Research Scheme and funded by Cancer Australia).

This combined approach has been studied, but its efficacy relative to that of chemotherapy alone is not known. Patients with stage III endometrial carcinoma treated with chemoradiotherapy in the ...

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Purpose: The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus radiotherapy alone (RT) for women with high-risk endometrial cancer (EC). Because The Cancer Genome Atlas …

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Methods. In the multicentre randomised phase 3 PORTEC-3 trial, women with high-risk endometrial cancer were eligible if they had International Federation of Gynaecology and Obstetrics (FIGO) 2009 stage I, endometrioid grade 3 cancer with deep myometrial invasion or lymphovascular space invasion, or both; stage II or III disease; or stage I–III disease …

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